I really doubt anyone will go NA, to play with 150-250 ping and paying a subscription. Maybe just to check the game... but i would really doubt that.
I have tested on the NA retail server and I have 130 ping, and it is completely playable in my opinion if you don't use classes like assassin, glad, etc.
It's a handicap I know, but I've always played chanter, advantage .
I will play it, even with that handicap, too many good moments will give me the game to say "I won't play because of the ping".